One of the signs of atherosclerosis is the intima-media thickness (IMT) in the common carotid artery (CCA). The development of atherosclerosis is a multifactorial process which besides the age depends on many other factors, including the states of the autonomic nervous systems. In 29 healthy volunteers (12 men and 17 women from 19 to 70 years) IMT of both CCA was measured using ultrasound duplex scanning. Millivolt-scale DC potentials were recorded from 5 sites on head with AG/AgCl electrodes. Scalp electrodes were situated in frontal, central and occipital positions by sagittal line as well as in left and right temporal areas according to 10×20 international scheme (reference electrode on the wrist). Electrode potentials and dermal resistances were controlled (Voipio at al., 2003). IMT correlated with age of volunteers: for the right CCA r =0.60 (p <0.001), for the left CCA r=0.51 (p =0.004). IMT was significantly (p=0.026) thicker in the right than in the left CCA in the volunteers over 45 years. The difference between the right and left IMT=0.10+/-0.04; N=19. DC potential in right temporal area was factor influencing IMT in the right and left CCA: F=5.04 (p=0.033) and F=7.14 (p=0.012) by ANOVA, accordingly. High-amplitude DC potentials in the right temporal area corresponded to high values of IMT in the right and left CCA. Onbas at al. (2007) showed that handedness was a significant factor of IMT asymmetry. In our investigations only right handers women had significant predominance of rightward asymmetry of IMT of the CCA in any age (p<0.05). Right frontotemporal area is representative of cortical afferents of sympathetic nervous system (Craig, 2005) and DC potentials in this area may reflect its activity. This suggestion was confirmed by the investigations of cardiovascular regulation (Fokin et al., 2010).Chronic stress related to the activation of sympathetic nervous system leads to increasing probability of thickening of artery wall (Roepke at al., 2012). The correlation of high sympathetic activity was most pronounced with respect to DC potentials of temporal area of the right hemisphere than of the left hemisphere (Fokin, et al., 2010). Increase of IMT of the CCA was associated with age and a rise of DC potential in right temporal area. The increase of DC potential probably reflected the activation of sympathetic nervous system. Significant rightward asymmetry of IMT of the CCA was found and it was particularly noticeable after 45 years.