Honey is used variously as food, flavour, energy source and medicine. Its medicinal effects continue to be subjects of research. Such investigations include the effects of honey on wound healing, inflammation and pain (1,2). We previously reported its anti-inflammatory and nitric oxide inhibitory effects (2). Therefore, the present study was designed to investigate whether tamsulosin an alpha 1 blocker has effect on the anti-inflammatory and analgesic effects of honey. Rats used for both analgesic and anti-inflammatory studies were divided into five similar groups. These groups comprises of five rats each. Group A and B received saline and indomethacin (5mg/Kg ) respectively, while group C received tamsulosin (3μg/kg) only, group D received honey (200 mg/Kg ) and tamsulosin, group E received honey (600mg/Kg ) and tamsulosin. All drugs were administered orally, pain was accessed chemically using the formalin paw licking model and thermally using the hot plate latency assay. Acute inflammation was accessed using carrageenan induced paw oedema. Values are means ± S.E.M. and statistical analysis was by ANOVA. The results showed that tamsulosin demonstrated analgesic effects in the formalin model by reducing the licking time in the early phase from 96.40±9.27 to 43.40±8.49s (p<0.05) and in the late phase from 79.0±8.26 to 46.20 ± 10.78s (p<0.05). It also enhanced the analgesic effect of honey in this model especially in the late phase for the 200 mg/Kg (control: 79.0±8.26 vs honey: 13.60± 2.34s, P<0.05) . However, both honey and tamsulosin did not produce analgesic effect in the hot plate test. In the anti-inflammatory study, tamsulosin did not produce anti-inflammatory effect but it abolished the anti-inflammatory effect of honey when administered together. The findings from this study show that alpha 1 adrenoceptor has the capacity to enhance the analgesic effect of honey in chemically induced pain but it inhibits its anti-inflammatory effects. On the other hand honey may be promoting its anti-inflammatory effects partly by stimulating alpha 1 adrenoceptor. Therefore, caution should be taken if subjects are receiving alpha-1 adrenergic blockers concurrently with honey administration especially if honey is been administered for the treatment of inflammatory conditions.