The hemocyte plays the role of both platelets and leukocytes in invertebrates. In mammals, two separate cell types exist including the platelet which has been assigned the role of hemostasis and the neutrophil which is an innate immune cell involved in fighting infection. However this separation is somewhat artificial and probably does not accurately represent the function of platelets and neutrophils. In fact the platelet likely contributes to both sterile inflammation and in host response to infections. In sterile injury in for example the liver the platelet arrives at sites of injury in seconds plugging sinusoids. This occurs via certain integrins and functions to permit the neutrophil to gain access to the site of injury. In infection in the liver, the platelet also contributes meaningfully. In fact, we have identified a novel patrolling mechanism for platelets in the sinusoids where a touch and go interaction continuously occurs with the intravascular macrophage of the liver, the Kupffer cell. When a bacterium is caught by Kupffer cells, the platelets touch but don’t let go and form an encapsulation around the microbe and prevent dissemination. If the microbe persists in the vasculature, the platelet also binds neutrophils and induces the formation of Neutrophil Extracellular Traps in the vasculature thereby helping to catch intravascular free-flowing bacteria. In fact the trapping can be improved 4-fold above the constitutive Kupffer cell trapping of bacteria. Clearly the platelet contributes to neutrophil recruitment to sites of sterile injury as well as to neutrophil and macrophage function to help eradicate infections.