Airplanes and motorways are repaired successfully when broken. Humans suffering from one of the many multifactorial diseases are rarely so; at best, their diseases are managed. Yet, mankind has been able to put a man onto the moon and to get him back healthily. It is not that we haven’t spent the same amount of money towards understanding and finding cures for these diseases. And it is not that we are linearly progressing towards curing these diseases: most new publications add more issues than they resolve. Lack of progress may be due both to the excessive complexity of the topic at hand, to a crisis in the handling of information and communication in the life sciences and health care, and to a reluctance to see the forest for the trees. By organizing the plethora of biomedical information into a new type of dynamic framework, more of the information that is acquired will work towards the understanding of health and disease. The basis of this framework will be a molecule based, structured model of the human. I will discuss the potential that Recon2, the March 2013 consensus reconstruction of genome-wide human metabolism, may already offer. Important here is the ready generation of millions of metabolic maps, one for each sequenced individual. I will also give examples of how conjunction of such a genomics driven approach with an equally individualized physiological approach may lead to new strategies of dealing with truly individualized medicine: differential network-based drug design, transcription clocks, drug detoxification and biomarkers thereof.