Financial, logistical and ethical factors all currently place a great strain on the provision of suitable training in integrative techniques to undergraduate students. In particular training and experience of in vivo drug screening techniques such as functional assays to evaluate the efficacy of potential compounds are particularly difficult to provide at an undergraduate level. Exposure to integrative techniques is very important and should be extended and supported whenever possible, however conventional animal models used in such relevant areas like behavioural pharmacology research (typically involving rodents) require considerable investment of time and resources and for large numbers of undergraduates, it is far from ideal from both an animal welfare and financial perspective. To overcome this, there are alternative models available which may be utilised, replicating drug screening in mammals, but based on research on invertebrates or lower order vertebrates e.g. Zebra Fish (Gerlai, 2003). The use of lower order vertebrates however only refines animal usage and is still costly and logistically hard to manage e.g. Home Office licence requirements, thus it is only the invertebrate models that offer a far more cost effective, easier to manage and possibly more ethical alternative; the latter also representing a significant contribution to replacement, refinement and reduction. In addition, the small size, short life cycle, and ease of experimental manipulation of invertebrate species provide a rapid, cost-effective means for teaching many of the standard drug screening techniques used in behavioural pharmacology. The justification for such an approach comes from early work utilising invertebrates in drug discovery centred on neuroethology (Hou et al. 2004). Stereotyped behavioural responses in invertebrates, particularly insects, have been successfully exploited to examine the effects and efficacy of drugs across a variety of different therapeutic areas (Manev & Dimitrijevic, 2005). One such potential non-mammalian model is the blowfly, Calliphora vomitoria. In preliminary studies, we have shown that their larvae actively seek dark locations if placed in natural light conditions; a condition in rodents ubiquitously applied for screening for anxiolytic drugs (Brotz & Borst, 1996). Groups of students were easily able to replicate those preliminary light/dark responses in the larvae and further extend the study to show similar responses to anxiolytic compounds as studies utilising rodents. Thus, by mimicking rodent anxiety-like responses, this assay using the blowfly larvae, C. vomitoria, has both the potential use as a novel, low cost method of teaching undergraduate students integrative techniques and possibly offers an alternative functional and toxicological screen for novel psychotropic agents.