The duplication of cellular contents and their precise, equal division between daughter cells is a characteristic of dividing cell populations. Successful achievement of this complex process is effected by a substantial repertoire of cellular machinery and associated controls. The latter ensures the appropriate completion of individual steps prior to the commitment to the next. Thus, for example, the integrity and completion of DNA replication is ensured prior to exit from S-phase. The final, irretrievable step in this cascade of cell division events is the separation of daughter cells, i.e. cytokinesis. As with other elements of the cell cycle, cytokinesis is a highly orchestrated event and recent studies have uncovered a critical role for Protein Kinase C (PKC) in this process. The relevant PKC-dependent properties, the redundancy of PKC action and the regulatory inputs via PKC will be described.
Life Sciences 2007 (2007) Proc Life Sciences, SA224
Research Symposium: PKC control of cell division
A. Saurin1, J. Durgan1, A. J. Cameron1, A. Faisal1, M. S. Marber2, P. J. Parker1, 2
1. London Research Institute, London, United Kingdom. 2. Kings College London, London, United Kingdom.
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