Urodynamics have been traditionally recorded in anaesthetised or tethered animals. We have evaluated a model for simultaneous measurement of urodynamic and haemodynamic parameters in conscious, freely moving female dogs via radiotelemetry. All experiments were conducted in accordance with UK legislation and local ethical guidelines. Four female beagle dogs (9-15kg) were surgically anaesthetised with propofol (70-80mg) and maintained with isofluorane anaesthetic (2% in 1:2 O₂/NO₂ mix) for implanting telemetry transmitters (D70-PCT) to measure bladder pressure, blood pressure, ECG and temperature. An additional catheter was sutured into the bladder and attached to an access port located under the skin to allow filling and emptying of the bladder. Animals were given appropriate antibiotic and analgesic treatment prior to and following surgery. After recovery, animals were habituated to saline bladder filling via an infusion line connected to the bladder access port. Animals were singly housed in metabolism cages during studies to allow urine collection, the size of the cages allowed free movement. The optimum infusion rate for each animal was determined using a theoretical natural diuresis rate of 360ml/hr [Hamaide et al, 2003] as a starting point, and for each animal was identified based on consistency of bladder fill volumes and pressure. After each study animals were returned to their home pens. All 4 animals’ bladder fill data was consistent over subsequent fills in the same day and subsequent days. Table 1 shows maximum threshold and micturition pressure, bladder fill volume, MAP prior to first bladder fill, MAP prior to final fill and optimal infusion rate for each animal [mean ± SEM (n)]. Simultaneous measurement of haemodynamic parameters showed that cystometry did not cause stress to the animals. In conclusion this model allows simultaneous measurement of urological and cardiovascular parameters in the absence of anaesthetic or restraint providing a useful means to evaluate the effects of drugs on urological and cardiovascular function.