Glaucoma is an asymptomatic, progressive optic neuropathy which loss of retinal ganglion cells and atrophy of optic nerve. Glaucoma is often accompanied by an increased intraocular pressure caused by worse intraocular liquid outflow. The severe psychical stress could increase the intraocular pressure and may be one of the important factors to influence the genesis and progress of glaucoma. Physical activity plays an important role in reducing psychological stress. Therefore, appropriate aerobic exercise, as one of the essential physical activity component, could reduce the intraocular pressure in glaucoma patients and prevents progress of damaging retinal ganglion cells. The aim of this pivotal study was to assess the impact of physical activity on dimensions of sense of coherence type resistance in glaucoma patients with correlation to blood and intraocular pressure. The study group consisted of 19 glaucoma patients-women, age 51.4±3.4 years. Intraocular pressure was measured twice before and after 3-month exercise program in eye clinic. Blood pressure (BP) was measured within week, 5 times a day before and just after each exercise session. The exercise group (n=11; mean age 48. 9±4.8 years) was enrolled in the 3-month aerobic exercise program twice a year. The control group (n=8; mean age 53.9±6.2 years), matched in age without any organized physical activity. Pharmacotherapy of all glaucoma patients was non-specific beta-blockers and prostaglandin analogue drops. The exercise program, with a frequency of 2 times per week and duration 55 to 60 minutes per session. The aerobic dance and fit ball aerobic exercises were alternated. The questionnaire was used to evaluate the psychological state (The Subjective Perception Scale SUPOS) with 7 components represented in its overall integrated structure. Values are means ± S.E.M., compared by ANOVA. The intraocular pressure varied before the intervention in the normal range and significant (p≤0.05) reduction was detected after the program in the exercise group, except one patient. After the intervention both the systolic and diastolic BP was no different from initial values with no significant fluctuation during the day. No significant changes of BP were detected in 35% of the exercise group immediately after the session, ranged only between 5-15%. The values of disintegrity block (uncomfortable feeling, depression, feeling of uncertainty and sad were higher (not significantly) in control group. In individual evaluation of values of activity block 50% of the subjects of control group and 91% of exercise group showed the values higher than 35% (as in non-clinical population). The results of our study suggest a positive impact of aerobic program on retention the risk factors of glaucoma patients.