Background: to analyze relationship between obesity, functionnal status and quality of life in patients with knee osteoarthritis, we have included 50 patients with knee osteoarthritis, the WOMAC and the OAKHQOL were used.Objectives: The association between obesity and knee osteoarthritis (OA), and specifically the role of obesity as a risk factor for knee osteoarthritis has been well documented. We aimed to explore relationship between obesity and functional status and quality of life (QoL) in patients with knee OA.Methods: 50 patients (mean age 59.04 [46-79] ± 8.98 years) with bilateral knee OA according to ACR criteria have been included. Functional status assessed by Lequesne and by the Moroccan version of WOMAC (Western Ontario and McMaster Universities Osteoarthritis) was compared between obese patients (BMI >30m/kg2) and non obese patients (BMI<30m/kg2).The Moroccan version of the osteoarthritis knee and hip quality of life questionnaire (OAKHQOL) was used to assess quality of life in the 2 groups. Because of the high percentage of illiteracy in Moroccan population, the WOMAC and the OAKHQOL have been filled by the investigator while interviewing OA patients (using face-to-face technique).Resultstable 1Conclusion: This study suggests that women suffering from knee OA have poor functional status and more disturbed quality of life domains of physical activities and pain. These data should be verified by larger studies.