Diabetes mellitus (DM) is a metabolic disorder with grievous pathophysiological complications. Methanolic extract of Ficus exasperata leaves has been reported to ameliorate various complications of the disease. This study was carried out to compare the ameliorative potentials of F. exasperata extracted with various solvents on diabetic albino rats. Thirty-five male albino rats divided into 6 treatment and one control groups were used for the study. DM was induced by single intraperitoneal injection of 200mg/kg alloxan monohydrate. The effects of treatment with 200mg/kg of n-hexane, chloroform, ethyl acetate and methanol extracts on the pathophysiology and histopathology of DM were studied. Test for secondary metabolites in all the extracts showed the presence of alkaloids, saponins, tannins and flavanoids. Hyperglycemia was reversed in all rats treated with the four extracts within 6 days of treatment. Blood glucose concentration was significantly lower (p<0.05) in rats treated with the extracts compared to the rats treated with glibenclamide. Rats treated with the chloroform and ethyl acetate extracts recorded the least blood glucose levels (93 and 97 mg/dl respectively). Rats treated with ethyl acetate fraction recorded the highest hematological values, least cholesterol and coronary risk index values. Also, chloroform and ethyl acetate fractions showed better liver and kidney function parameters. Various degenerations observed in the pancreas, kidney, liver and heart were milder in rats treated with ethyl acetate extracts compared to others. Results from this study have demonstrated that ethyl acetate extract of F. exasperata has best ameliorative effects on the pathophysiology and histopathology of DM.