Cerebral perfusion increases during low-to-moderate intensity dynamic exercise by ≈10-30% in regions such as the motor-sensory cortex and supplementary motor area where cerebral neuronal activity and metabolism are elevated. Beyond ≈60% maximal oxygen uptake, cerebral vasoconstriction occurs and cerebral perfusion declines towards resting levels, substantively due to a hyperventilation mediated reduction in the partial pressure of arterial carbon dioxide (PaCO2). A lower cerebral perfusion is observed in older individuals, both at rest and during incremental dynamic exercise (Fisher at al., 2008, 2013). While a host of factors likely contribute (e.g., brain atrophy), an age-related reduction in PaCO2 during exercise has been noted, which when corrected for by the provision of supplementary CO2 ≈50% of the difference in cerebral perfusion between young and older individuals is removed (Fluck et al., 2014). The arterial-jugular venous differences for oxygen, glucose, lactate, and the molar ratio between cerebral uptake of O2 versus carbohydrate (O2-carbohydrate index; O2/[glucose + 1/2 lactate]) are similar in young and older individuals exercising at an equivalent submaximal workload (i.e., matched relative intensity) (Fisher at al., 2013). Thus, despite the reduction in cerebral perfusion during exercise the healthy elderly brain appears to maintain its ability to take up nutrients. Intriguingly, during fatiguing dynamic exercise reductions in cerebral oxygenation are similar in young and older despite the much lower maximal workload in the older group. A caveat to the published studies examining the influence of age on cerebral perfusion during exercise is that volumetric flow has not been described and instead a reliance has been placed upon transcranial Doppler ultrasound derived middle cerebral artery blood velocity to index cerebral perfusion. Further studies are required to address this, and to provide a more detailed assessment of the regional influence of age on cerebral perfusion, oxygenation and metabolism during exercise. Such investigations may further our understanding of the mechanisms for the purported benefits of physical activity on cerebrovascular health in the elderly (e.g., shear stress) and support the utility of acute exercise as a means of identifying the existence of age-related deficits in the brain.