Background and Aim: Salt consumption has been increased worldwide and the association of high salt diets with enhanced inflammation and target organ damage was reported. Little data were available about the effect of high salt diet on exocrine function of pancreas, while the relation between high salt intake and insulin sensitivity were controversial. This study was designed to investigate the effect of high salt diet on exocrine and endocrine pancreatic functions, and to elucidate the possible underlying mechanism(s). Materials and Methods: 20 adult female Wistar rats were randomly divided into 2 groups; control group; fed standard rodent diet containing 0.3% NaCl, and high salt fed group; fed 8% NaCl for 8 weeks. On the day of sacrifice, rats were anaesthized by i.p. pentobarbitone (40 μg/kg B.W.). Nasoanal length was measured and fasting glucose was determined in blood samples obtained from venipuncture of the tail vein. Additional blood samples were obtained from the abdominal aorta under anaesthesia for determination of plasma sodium, potassium, amylase, lipase, aldosterone, insulin, TGF-β1and IL6. Pancreata of both groups were histologically studied. Results: Compared to control group, 8 week-high salt fed group showed: significant elevation in body weight, body mass index, Lee index, plasma sodium, TGF-β1 and IL6, however, plasma aldosterone, amylase, lipase and insulin levels were significantly decreased. A non-significant increase in plasma potassium and non-significant changes in fasting blood glucose and HOMA-IR were detected between groups. Pancreatic fibrosis was observed in test group. Conclusion: High salt diet for 8 weeks caused pancreatic fibrosis evidenced by decline of both exocrine and endocrine functions of pancreas in Wistar rats.