Introduction/ Objectives: Shisha smoking (also known as Water pipe, Hubble bubble, Arghile) is becoming a global phenomenon in the past few years and inhalation of shisha expose our body to hazardous substances like charcoal, nicotine, arsenic, cobalt, chromium and lead etc which may lead to many life-threatening diseases including lung cancer, mouth cancer and urinary bladder Cancer. The aim of this study is to assess whether there is any difference in the lung function indices of those who smoke shisha as compared to non shisha smokers. Methodology: 152 shisha smokers and 153 age matched non shisha smokers (between 18-35 years of age), who were all non-cigarette smokers and had no apparent lung diseases were recruited for this study. All subjects were volunteers and underwent screening with detailed history, anthropometry and spirometric measurements. The study was approved and supported by department of health management, Institute of Business Management, Karachi, Pakistan Results: There was a significant reduction in the force vital capacity (FVC) [mean difference (95% CI) 0.54L (0.45, 0.64) P < 0.001], force expiratory volume in first second (FEV1) [mean difference (95% CI) 0.52L (0.43, 0.61) P < 0.001], and peak expiratory flow (PEF) [mean difference (95% CI) 78.6L/min (65.2, 92.04) P ≤ 0.001] in the shisha smokers as compared to the control individuals. The study also indicated that most of the shisha smokers these days are educated young adults who smoke shisha for pleasure (79.5%) or for a social status or for friends. Most of the subjects heard about the shisha smoking either from their friends gathering (85.4%) or from their educational institute (13.2%) indicating that shisha smoking is getting common among educational institutes as well. It has been found that most of the shisha smokers smoked it occasionally (54.3%), and some do it either monthly (14.6%) or weekly (13.9). Conclusion: It can be concluded from this study that shisha smokers had statistically significant lower FVC, FEV1 and PEF as compared to the non shisha smokers. Therefore, it is suggested that government and regulatory bodies should take necessary steps to implement the law regarding selling and use of shisha smoking in close cafes and in public places as this would help in reducing the morbidity and mortality associated with respiratory complications secondary to shisha smoking in younger age group.