Our research has been focusing on deciphering intracellular mechanisms that enable hypothalamic cells to sense and respond to changes in circulating nutrient and hormone levels in the control of systemic energy and glucose metabolism. Our recent findings have unmasked mitochondria as critical intracellular organelle in detecting changes in peripheral metabolism. By altering their size, shape and function, mitochondria enable cells to adjust their activity, which in turn alter behavior and peripheral tissue functions to fine tune systemic metabolism. This presentation will highlight these cellular biological process in the hypothalamic regulation of energy and glucose homeostasis.
Europhysiology 2018 (London, UK) (2018) Proc Physiol Soc 41, SA026
Research Symposium: Mitochondrial dynamics in metabolism regulation
S. Diano1,2,3,4,5
1. Program of Integrative Cell Signaling and Neurobiology of Metabolism, Yale University School of Medicine and Graduate School, New Haven, Connecticut, United States. 2. Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine and Graduate School, New Haven, Connecticut, United States. 3. Department of Neuroscience, Yale University School of Medicine and Graduate School, New Haven, Connecticut, United States. 4. Department of Comparative Medicine, Yale University School of Medicine and Graduate School, New Haven, Connecticut, United States. 5. Dept. Clinical Medicine and Surgery, University of Naples "Federico II", Naples, Italy.
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