Aim: The present work aimed to clarify the potential beneficial effects of green tea and exercise training in alleviating hemostatic derangements in experimental hyperthyroidism highlighting the possible underlying mechanism(s). Methods: 46 adult male Wistar rats were divided into four groups: control, hyperthyroid, green tea supplemented hyperthyroid and exercise trained hyperthyroid. Rats (260-330g) were anaesthetized with thiopental sodium (40mg kg-1) and were subjected to determination of body weight (BW), body mass index (BMI), serum levels of free triiodothyronine (FT3), free thyroxine (FT4) and thyroid stimulating hormone, complete blood picture, prothrombin time (PT), activated partial thromboplastin time (APTT), plasma levels of fibrin degradation products (FDPs), malondialdhyde (MDA) and catalase activity and C-reactive protein (CRP). Results: Hyperthyroid group showed significantly decreased BW, BMI and their percentage change, prolonged PT and APTT, elevated plasma FDPs, reduced platelet count and plateletcrit, increased white blood cell (WBC) count and plasma MDA level and decreased catalase activity. Green tea supplementation significantly decreased serum FT3, increased BW and BMI and their percentage changes, shortened PT and APTT, decreased WBC count and CRP and increased catalase activity as compared to hyperthyroid group. Exercise-training significantly reduced serum FT3 and FT4, shortened PT and decreased plasma MDA, WBCs count and serum CRP as compared to the hyperthyroid group. Platelet count and plateletcrit were increased in both green tea and exercise groups and reached control values. Conclusion: Both green tea and exercise training attenuated the hemostatic abnormalities mediated by hyperthyroidism, an effect probably owed to its antithyroid, antioxidant and anti-inflammatory activities.