Type 2 diabetes mellitus (T2DM) has become a global health challenge (Baynest, 2015). The search for it remedy across different available agents with medicinal value may elucidate the health burden imposed by the disease. Studies on clove and ginger revealed their medicinal potency in ameliorating metabolic disoders. However the effects of these supplements on oxidative stress biomakers in type 2 diabetes still suffers’ elusive scientific explanations (Tapsell et al., 2006). Oxidative stress plays a pivotal role in progress and complications of the disease. This study aimed to evaluate the effects of clove and fermented ginger supplements on oxidative stress and lipid peroxidation biomarkers in high fat diet (HFD) induced type 2 diabetic rabbits. Method Rabbits were handled in accordance with the principles guiding the use and handling of experimental animals, ABU, Zaria. Ethical approval was obtained, with Approval No: ABUCAUC/2017/048. HFD was fed to rabbits (New Zealand breed) for eleven weeks to ascertain diabetic animal model (DAM) (Jimoh et al., 2015). Thereafter, DAM were treated with supplements for six weeks. Thirty male rabbits (8-10 weeks of age) divided into six groups (n=5) were used for the study. Group I (Normal control) fed on standard animal feed (SAF) only, Group II-VI were (DAM groups): [Group II, fed SAF only (diabetic control), Group III = SAF + cholestran (0.26 g/kg), Group IV = SAF + clove buds (12.5%) supplements, Group V = SAF + fermented ginger (12.5%) supplements, and Group VI = SAF + clove buds (12.5%) + fermented ginger (12.5%)]. At the end, animals were humanely sacrifice and serum was used for assessments of superoxide dismutase (SOD), catalase (CAT) and malondialdehyde (MDA) concentrations using standard laboratory procedures (Schmidt and Schmidt, 1976). One way ANOVA, with Tukey’s Post-Hoc Test was used to analysed the data generated, the results were presented as mean ± SEM. The results shows a significant increase (P < 0.05) in CAT concentration in group V compared to diabetic control group and also indicate a significant (P < 0.05) increased SOD and CAT concentrations, and a decrease in MDA level in group VI compared to diabetic control group. In conclusion, the observed increased oxidative stress enzymes and decreased lipid peroxidation marker in the treatment groups indicates ameliorative activity of the individual supplements on oxidative stress and importantly a synergistic effect was observed when they are combined, this may be attributed to presence of flavonoids, phenolic and other active constituents (Park et al., 2011; Rahmani et al., 2014; Hsu et al., 2015 ) in the supplements. Hence, the combination of these supplements should be futher studied for their consideration among diets content to ameliorate diabetes pathologies.