By using Wistar albino Glaxo rats of Rijswijk (WAG/Rij) rats, we have previously documented that there may be increased sensitivity for acute pain in epilepsy (1) but it is not clear whether the case is also valid for chronic pain. The aim of this study was to investigate chronic neuropathic pain sensitivity in WAG/Rij rats, in comparison with normal Wistar rats. The WAG/Rij groups consisted of asymptomatic (2 months old) and symptomatic (5 months old) males and sex -matched healthy Wistars (5 months old) served as control. Neuropathic pain was induced by schiatic nerve chronic ligation under general anaesthesia. Pain sensitivity was assessed, one week after schiatic nerve injury, by using mechanical (von Frey test) and heat-induced (plantar test) behavioral pain tests, which was performed in interictal period (in symptomatic group). Measurements were performed as animals were awake and freely moving. Post-operative pain sensitivity was measured in contralateral hind-paw of sciatic nerve constricted leg. Statistical analysis of pain threshold values were performed by use of paired sample t test and Dunnett’s test as follow-up to two-sample ANOVA. P<0.05 was accepted as statistically significant. All protocols were approved by the Ethical Committee on Animal Experimentation of Karadeniz Technical University. Schiatic nerve injury caused a significant increase in mechanical pain sensitivity in Wistar (74.5±16.3 sec vs. 57.3 ±15.1 sec, P<0.02, n=8, pre-op vs. post-op, respectively). Simlarly non-symptomatic WAG/Rij rats showed increase in pain sensitivity, although not statisticly significant, following schiatic nerve injury (43.4±4.5 sec vs. 35.1 ±8.1 sec, P>0.20, n=8, pre-op vs. post-op, respectively). But in symptomaitc WAG/Rij rats an opposite effect was observed following chronic nerve ligation (37.3±2.5 sec vs. 69.8 ±2.5 sec, P<0.001, n=8, pre-op vs. post-op, respectively). Similar pain sensitivity change profiles were observed in heat-induced pain responses of symptomatic epileptic WAG/Rij rats compared to control Wistar and asymptomatic WAG/Rij rats. Results from this study indicates that epileptic WAG/Rij rats develop different response to chronic neuropathic pain, this is despite they having higher nociceptive pain sensitivity compared to healthy Witars under basal conditions, following chronic constriction injury of the schiatic nerve. The possible mechanism underlying this response is not clear and deserve further investigation.