Maximum inspiratory pressure (MIP) is a measure of inspiratory muscle strength which decreases with age and is higher in men compared to women (1). Physical Activity on regular basis helps to maintain it (2), so some authors have analysed its relationship with regard to functional capacity in aging and pathology (3). However, up to our knowledge this is the first study to analyse any mediating influence of age and gender in this association, considering healthy active elderly. 67 healthy, active, non-smokers elderly (73.02±4.54 years; 48.96±16.93 cmH2O, 55 women) volunteered to participated. Twice a week, they underwent 60 min of EFAM-UV©, a multicomponent training program (MCTP) focused on gait training, postural control and strength training under dual-task constraints (4). Body composition and functional capacity were assessed, followed by correlation analyses between MIP and functional capacity (6MWT, Hand Grip [HG] and 30 seconds seat to stand test [30STS]), with age and gender as covariates. Age and gender influence on MIP and functional capacity was previously tested. Despite being trained (Table 1), our sample showed similar MIP compared to recent studies assessing it with the same electronic device (Powerbreathe©K5) (5). As expected, age (a) and gender (g) confirmed their influence on MIP (ra=-0.297; p<0.05, rg=0.444; p<0.005) and functional capacity (6MWT: ra=-0.348; p<0.005, rg=0.348; p<0.005, HG: ra=-0.417;p<0.005, rg=0.637; p<0.005). In addition, the association between MIP and functional capacity was clearly reduced by both covariates, with gender as the main mediator (6MWT: r=0.468; p<0.005 vs ra=0.397, p<0.005, rg=0.360, p<0.005, HG: r=0.493; p<0.005 vs ra=0.404; p<0.005, rg=0.270; p<0.05, 30STS: r=0.305; p<0.05 vs ra=0.276; p<0.05 vs rg=0.260; p<0.05). Whereas 6MWT and 30STS displayed an almost small association with MIP when accounting for age and gender together, this association disappeared in HG (6MWT: r=0.468; p<0.005 vs ra+g=0.286; p<0.05, 30STS: r=0.305; p<0.05 vs ra+g= 0.234; p=0.061). Current disparity in the normative scores for MIP prevent to conclude that general neuromuscular health does not ensure respiratory functioning (i.e. optimal inspiratory strength), although small values or absence of correlation with MIP (HG), when accounting for age and gender, suggest it. Higher cardiorespiratory demands in 6MWT and 30STS might explain their slightly larger association. Specific respiratory training and MIP measurement might be introduced to ensure respiratory health in active elderly undergoing neuromuscular MCTPs.