Gravity causes a hydrostatic pressure gradient in fluid-filled bodily compartments. Accordingly there is a significant displacement of blood to the lower parts of the body with a reduction in the central blood volume when turning from supine to the erect position. Local and central regulatory mechanisms are activated to maintain the arterial blood pressure and to prevent edema in the limbs below the heart level (1). Consequently, the blood flow to the skin of the foot is reduced by localized vasoconstriction called veno-arteriolar reflex (VAR) (2). The aim of our study was to measure the response of skin blood flow in the foot to hypogravity conditions, simulated by wearing the anti-gravity socks (AGS) at rest and after short lasting aerobic exercise. In nine young healthy volunteers laser-Doppler skin blood flow (LDF) was measured in two skin spots on the foot: glabrous and non-glabrous skin with different vascular anatomy (thermoregulatory and (or) nutritional microcirculatory network) and different vascular sympathetic innervation (adrenergic or cholinergic). Measurements were conducted with and without AGS at rest and after submaximal cycling. In order to avoid the influence of arterial blood pressure to cutaneous blood flow, cutaneous vascular conductance (CVC) was calculated as LDF divided with mean arterial pressure, which was measured simultaneously. At rest, statistically significant hyperperfusion was found in glabrous (LDF: 87,06±15,93PU with AGS compared to 56,51±12,48PU without AGS; P=0,04; CVC: 0,97 ± 0,17 PUmmHg-1 with AGS compared to 0,66 ± 0,16 PUmmHg-1 without; P=0,003), as well as in nonglabrous skin (LDF: 9,41±1,54PU with AGS compared to 6,76±1,15PU without AGS; P=0,04; CVC: 0,111 ± 0,003 PUmmHg-1 with AGS compared to 0,075 ± 0,004 PUmmHg-1 without; P=0,004) in hypogravity conditions. After exercise, there were no statistically significant differences in LDF and CVC in any skin sites with respect to AGS. Our results indicated that in hypogravity conditions VAR is absent in glabrous as well as in nonglabrous skin at rest. On the contrary, after physical exertion, these differences in skin perfusion disappeared in both skin spots indicating that other mechanisms and not VAR regulates the skin blood flow to the lower limb after exercise. Increased blood flow through arteriovenous anastomoses in glabrous skin and activation of vasodilatory cholinergic sympathetic nerves to the nonglabrous skin vasculature could be proposed mechanisms. Exercising in hypogravity conditions would be beneficial with respect to VAR to avoid edema in the lower limbs at rest.