Whole grain consumption is being regarded as a safe approach for management of metabolic disorders. Millets are also whole grains and their consumption has been shown to be inversely associated with metabolic diseases. Finger millet (FM), known as (Eleusine coracana) is an important food crop among Africans and Indians. It is regarded as “wonder grain/super cereal” due to health promoting effects. Heavy metals such as mercury, when exposed to, pose a great health problems.When absorbed, inhaled or ingested into the blood stream, they damage tissues like the kidney, brain and liver. Urea, creatinine, and serum electrolytes, (sodium, Na+, potassium, K+, chloride, Cl- and bicarbonate, HCO3-) are very important parameters for maintaining the body’s fluid balance. Their imbalance result in several disorders such as dehydration. This study was designed to investigate the effect of finger millet on urea and serum electrolytes in mercury chloride (Hgcl2) induced toxicity in wistar rats. The rats were randomly divided into five groups of five rats each (n=5). Group 1 (control) were administered with distilled water (2.5ml/kg), Group 2 were given 6.23mg/kg (3.75%) of Hgcl2 and 100mg/kg of finger millet, Group 3 were given same dose of Hgcl2 and 50mg/kg of finger millet, Group 4 also received same dose of Hgcl2 and 25mg/kg of finger millet while Group 5 received Hgcl2 only, all treatments were administered via oral route. After two weeks of administration, rats were euthanized and blood samples were drawn from the heart by cardiac puncture and used to assay for serum urea, creatinine, sodium, potassium, chloride and bicarbonate. Analysis of variance (ANOVA) and Turkey’s post hoc test were used to analyse the data obtained. The result showed a significant (P<0.05) decrease in serum creatinine from the group treated with 50mg/kg and 25mg/kg (63.08 ±3.22 and 62.12 ±4.08) when compared with the normal control (79.18 ±1.90) group. Also there was a significant (P<0.05) decrease in serum potassium level from the group treated with 50mg/kg (4.95 ±0.29) when compared with the control (79.18 ±1.90) group. Furthermore there was no significant difference (P<0.05) in serum level of Urea, Sodium, Chloride and Bicarbonate when compared with the normal control group. The present study suggest that finger millet could be used as a supplement to improve the toxic effect induced by mercury chloride.