Muscle strength is a function of muscle size and neural mechanisms and is important for the completion of tasks associated with daily living, including walking and standing balance (1). Such tasks are conducted by multiple muscles in unison, meaning intramuscular factors, neural capacity and levels of muscle coordination are all required for efficient and successful movement (1). Muscle strength decreases at a greater rate than muscle mass in older age (2), with a concurrent age-related decrease in the level of motor control (MC; 3), both of which are largely explained by neuromuscular factors including declines in motor unit (MU) number and the influence of MU remodelling (4). Although forms of exercise training, such as resistance exercise, may attenuate these decrements and improve neuromuscular function (5), these are often unachievable for older individuals. We therefore investigated whether targeted motor control training (MCT) could lead to improved muscle functional capacity and control, and alterations of individual MU function. Six healthy young volunteers (4 females; age, 25.2±5.8 years; BMI, 22.5±4.0 kg.m-2) underwent a 4-week supervised multiple-muscle MCT intervention. MCT was completed unilaterally, 3 x per week, consisting of 6 complex isometric muscle contractions for the knee extensors (KE) and dorsi flexors (DF) in a randomised order at 10, 25 and 40% of an individuals predetermined maximal voluntary contraction (MVC). Levels of MC, derived from complex oscillating force tracking tasks (differing to those completed as part of MCT), were represented as the level of deviation from the target line. Straight line force steadiness (FS) was additionally determined at 10, 25 and 40% MVC. Intramuscular electromyography (iEMG) was utilised to sample individual MUs from the vastus lateralis (VL) and tibialis anterior (TA) muscles during sustained contractions, prior to and post intervention. Data were analysed by paired Student’s t-test, with statistical significance accepted at p<0.05. Both MVC and FS showed no differences for KE and DF following 4 weeks MCT. KE complex forcing tracking improved following MCT at 10% MVC (-39.24%, p=0.005), 25% MVC (-28.62%, p=0.043) and 40% MVC (-29.13%, p=0.015). DF complex force tracking also significantly improved post intervention at each contraction intensity (10% MVC, -25.73%, p=0.002; 25% MVC, -33.35%, p=0.0006; 40% MVC, -30.06%, p=0.049). Although MU firing rate (FR) remained unchanged across both muscles, FR variability significantly reduced post intervention in VL only (n=5; -16.36%, p=0.031). Our results suggest improved levels of MC following MCT at different contraction intensities and, importantly, across different muscle groups. Such improvements in MC may be explained by the observed reduction in FR variability. These data from young individuals suggest MCT may lead to substantial improvements or maintenance of muscle control in older adults, an area to be subsequently explored, to aid mechanistic insight into the plasticity of movement control across the lifespan.