In this talk I will give a brief introduction to one of the new projects in which Denis is playing a leading role – the EPSRC-funded Integrative Biology e-Science Pilot Project. This project aims to begin to build a computational infrastructure for Physiome-style modelling, focusing initially on modelling of the heart and of cancer. The aim is to build a user-friendly, transparent system that allows seamless use of: high-performance computing facilities; state-of-the-art visualisation and collaborative visualisation techniques; computational steering; and advanced data management technologies. The project has close links with many of the first round of UK e-Science pilot projects, and therefore builds extensively on existing Grid Middleware. I will end by giving a brief overview of the presentations made during this two-day workshop, and will attempt to draw out areas of potential synergy arising across the broad range of applications and across the spatio-temporal scales that will be considered.