Lymphedema is a common side-effect of cancer treatment which involves surgical removal of lymph nodes resulting in disruption of lymph drainage. This leads to swelling and reduced strength and mobility in the effected part. In breast cancer patients this often affects the arms and can be very painful and debilitating. Exercise therapy has been shown to reduce the side-effects of cancer treatment. This study investigates the effects of exercise therapy in improving upper limb mobility and other fitness related variables in breast cancer survivors suffering from lymphedema. This study was conducted as a non-randomized pilot study. 4 breast cancer survivors clinically diagnosed with lymphedema were assigned to group A (lymphedema group). An additional 4 breast cancer survivors without lymphedema were assigned to group B (non-lymphedema group). All enrolled participants had completed cancer treatment 2-6 months prior to this study. For each outcome baseline characteristic was assessed at the initiation. Both groups participated in a multi-component exercise program, which included aerobic, resistance and flexibility exercises for 8 weeks. Additional lymphedema specific exercises were also prescribed to enhance lymphatic drainage. Outcomes were measured every 4 weeks and included range of motion, flexibility, strength and 1RM on resistance machines, limb circumference, balance and aerobic capacity. All parameters improved significantly after 8 weeks but there was no significant difference between the two groups. Range of motion of the shoulder was shown to have similar improvements in both. Both groups showed significant progression in balance, flexibility and strength. Evaluation of strength revealed that group B progressed on all upper body machines, while group A showed greater progression in chest-press, shoulder-press and lateral pull-down. Limb circumference measures (lymphedema arm) reported only a small improvement between the initial and final assessment, this may be due to the resistance component of the program resulting in increased muscle tone. Nevertheless, all enrolled participants reported a positive change in their current quality of life on completion of the study.  Exercise therapy was shown to improve mobility and strength in cancer survivors suffering from lymphedema. However; a longer interventions (> 8 weeks) is needed to promote significant improvement in lymphedema status.