Human cervical carcinogenesis is accompanied by the over-expression of mRNA transcripts for KCC 1, KCC 3 and KCC 4. KCC 3 is the most abundant isoform in these cells, where its function may be in cell proliferation. Following expression in 3T3 cells, KCC 3 is not involved in RVD, and is not activated by hypotonic shock. There is differential expression of KCC 3 during the cell cycle. Inhibition of KCC 3 with DIOA or a dominant negative leads to inhibited cell growth and decreased tumour potential.
University of Manchester (2003) J Physiol 552P, SA7
Research Symposium: A role for KCCs in human cervical carcinogenesis
J.C. Ellory and M.R. Shen
University Laboratory of Physiology, University of Oxford, Parks Road, Oxford OX1 3PT, UK
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Where applicable, experiments conform with Society ethical requirements.