Vascular oxidative stress has been demonstrated in spontaneous (genetic) hypertension (1). Hydrogen sulfide (H2S) has been recognized as a potential antihypertensive agent in various forms of experimental hypertension (2). The present study was aimed to evaluate the antioxidant potential of hydrogen sulfide in SHR. NaHS was used a s a donor of H2S. For in vivo study WKY and SHR rats were divided in 4 groups namely WKY (I), WKY + NaHS (II), SHR (III) and SHR + NaHS. Groups II and IV received NaHS at a dose of 56 µM/kg i.p. daily for 4 weeks. Blood pressure, renal cortical blood perfusion and pulse wave velocity were measured in acute study under pentobarbitone anesthezia (60mg.kg-1). In vitro , NaHS was found as a free radical scavenger, reductant and inhibitor of lipid peroxidation. In vivo study showed NaHS treatment reduced blood pressure, increased renal cortical blood perfusion and increased H2S and NO plasma levels, and up-regulated the antioxidant defenses in SHR. The findings of this study suggest that the administration of NaHS not only reduces the blood pressure but also attenuates the oxidative stress in spontaneously hypertensive rats.
37th Congress of IUPS (Birmingham, UK) (2013) Proc 37th IUPS, PCC052
Poster Communications: Administration of hydrogen sulfide attenuates the oxidative stress in spontaneously hypertensive rats
H. A. Rathore1, F. ud Din1, M. A. Sattar1, A. I. Hussain1, T. Y. Chia1, N. A. Abdullah2, E. J. Johns3
1. School of Pharmaceutical Sciences, Universiti Sains Malaysia, Pulau Pinang, Malaysia. 2. Faculty of Medicine, Universiti Malaya, Kuala Lumpur, Malaysia. 3. Department of Physiology, University College Cork, Cork, Ireland.
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