Aging is a normal process of adult life characterised by a gradual decline in the physiologic reserves. Physiologic functioning is probably a better measure of aging than chronological age. Elevated plasma fibrinogen concentration has been linked severally with cardiovascular diseases and stroke in the elderlies and the influence of plasma Fibrinogen concentration on plasma viscosities is well understood.Our interest was primarily based at establishing Fibrinogen index in Geriatrics especially in the Nigeria and secondly to assess their rheological parameters as probable indices of their cardiovascular function. A total of 50 apparently healthy, elderly Nigerians with ages between 60 and 85 years comprising of 25 males and 25 females recruited from old people’s home and some individuals around the southern area of Nigeria were studied for hemorheological parameters such as: Packed cell volume (PCV), Plasma and whole blood viscosity (PV and WBV respectively), Erythrocytes sedimentation rate (ESR), Plasma Fibrinogen concentration(PFC) and Euglobulin lysis time (ELT). They were compared with 50 healthy younger sex -matched subjects (controls).We observed statistically significant increases in the values of PV, PFC, ESR and ELT while PCV and WBV exhibited significant decreases when compared with controls (P<0.05, respectively). The increase in ELT is interpreted as a reduction in fibrinolytic activity.In conclusion, decreased haematocrit and lowered whole blood Viscosity coupled with hyperfibrinogenaemia with subsequent high plasma viscosity and hypofibrinolysis could be reflections of advanced age. The decreased parameters may favour improved hemorheology at the onset but the overwhelming influence of the elevated parameters are indicative of abnormal rheology and a predisposition to thrombotic tendencies and other cardiovascular complications at old age. The need for exercise and prophylactic antithrombotic therapy especially at advanced ages may be indicated.
Ageing and Degeneration (Edinburgh, UK) (2015) Proc Physiol Soc 33, PC29
Poster Communications: Altered hemorheological indices in a Nigerian geriatrics population
O. I. AJAYI1,2
1. PHYSIOLOGY, UNIVERSITY OF BENIN, Benin city, EDO, Nigeria. 2. MEDICAL LABORATORY SCIENCE, AMBROSE ALLI UNIVERSITY, Ekpoma, Edo, Nigeria.
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Where applicable, experiments conform with Society ethical requirements.