Abstract: Doxorubicin (DOX) is a broad spectrum antitumor antibiotic widely used clinically as an anti-cancer agent. Doxorubicin (Adriamycin) is measured as one of the most effective anti-cancer drugs. DOX has a sheer and widespread organ toxicity, which makes it to be reconsidered as a chemotherapeutic agent for cancer patients. Although cardiotoxicity is the main side effect for DOX use, renal anomalies have also been seen in patients receiving the drug, Doxorubicin has been found to compromised kidney function as depicted by increased sodium and chloride ions concentration and decreased bicarbonate ion concentration in the blood This project work attempts to evaluate the ameliorative effect of resveratrol on kidney function in doxorubicin-induced toxicity in wistar rats. 28 wistar rats were grouped into four groups of 7 Wistar rats each (n=7). Group A (control group) received only distilled water and normal feed; Group B (positive group) were administered resveratrol only dose of 20 mg/kg at zero hour and 24 hour of the experiment; Group C (Acute rat models of DOX-induced toxicity) were administered 20 mg/kg of DOX. Group D (Treatment group) received DOX (20 mg/kg) simultaneously with resveratrol (20 mg/kg). The experiment lasted 48hrs. The animals were handle according to the principle guiding the use of laboratory animals in Ahmadu Bello University, Zaria, Nigeria. At the end of the experimental protocol, the rats were placed under light anaesthesia of ketamine and diazepam to remain unconscious. The animals were dissected to expose the heart. After which about 4 ml of blood was drawn via cardiac puncture for urea electrolyte analysis. it can be concluded that resveratrol improves the concentration of serum chloride and bicarbonate, improved renal creatinine clearance in doxorubicin induced toxicity in wistar rats. Notably, resveratrol impeded the renal clearance of urea indicating potential kidney damage by resveratrol.