Risperidone is a second-generation atypical antipsychotic drug currently used for the management of psychosis related schizophrenia, delusional psychosis and psychotic depression, an action ascribed to its being a dopamine antagonist possessing anti-serotonergic, anti-adrenergic and anti-histaminergic properties. However, there are indications that risperidone have gastroprotective effect. This study was carried out to examine the effect of risperidone on stress-induced and indomethacin-induced ulcers in the rats. Rats were treated with risperidone (0.1mg/kg, 0.3mg/kg and 0.5mg/kg) orally once daily for 21 days before assessing for ulcer using water immersion restraint stress (WIRS) according to the method of Byun et al., 2007, starvation (Elegbe, 1978) and indomethacin-induced ulcer (Elegbe, 1978) models. The animals were handled in accordance with principles of laboratory animal care and use (NIH, 1985). Gastric lesions were scored and assessed using previous methods (Alphin and Ward, 1967; Elegbe and Bamgbose, 1976). Morphometric studies were performed using Olympus light microscope (x100) fitted with Casio digital camera and Motic plus China, 2000 software. Statistical analysis of data was done by one-way analysis of variance (ANOVA) and Student’s t-test for paired data using Graphpad prism software version 5 and were expressed as Mean ± SEM (Standard Error of Mean). Risperidone caused a significant dose-dependent reduction in gastric ulcer scores [0.1mg/kg (3.5±0.2), 0.3mg/kg (1.9±0.3), 0.5mg/kg (1.2±0.2)] compared with control (5.6±0.3) in WIRS; [0.1mg/kg (4.0 ±0.3), 0.3mg/kg (2.3±0.2), 0.5mg/kg (1.8±0.2)] compared with control (6.1 ± 0.3) in starvation and [0.1mg/kg (4.9±0.3), 0.3 mg/kg (2.0±0.2), 0.5 mg/kg (1.3±0.2)] compared with control (6.4±0.4) in indomethacin-induced ulcer models. The findings suggest that risperidone has gastric anti-ulcer property. However, more detailed studies are necessary to confirm the relevance of this finding and its implications in clinical settings.