Diabetes mellitus, an endocrine and metabolic disorder characterized by hyperglycemia and low blood insulin levels or insensitivity of target organs to insulin (Maiti et al., 2004) affecting quality of life due to its complications. Infertility is a major complication in diabetes (Koroglu et al., 2015; Vlad et al., 2016) due to histomorphological damage of epididymis and testes (Ghanbari et al., 2015), decreased sperm motility (Saumya et al., 2016), semen volume (Adedara et al., 2015), abnormal sperm morphology (Afifi et al., 2015) and disruption of seminiferous tubule morphology (Rashid et al., 2015). Though various agents have been used for intervention studies on diabetes-induced infertility globally, there are no current treatments for diabetes associated infertility in humans (Shi et al., 2017). Annona muricata leaf extract (AMELE) have been demonstrated to have anti-oxidant and anti-diabetic activities in animals (Feng 1962; Vasquez, 1990; Oladipo et al., 2018)). This study was performed to investigate the effects of AMELE on reproductive dysfunctions of male diabetic rats. Thirty-five male rats (150-200g) were randomly assigned to 4 groups (n=5): CTRL (control); DNT, DT1 and DT2 (diabetic, intraperitoneal injection, streptozotocin, 60 mg/kg once). DT1 and DT2 received AMELE orally at 100 mg/kg and 200 mg/kg respectively daily for fourteen days. Data were analysed using ANOVA at α0.05. The animals were sacrificed after 2 weeks and testicular weights were recorded. Fasting blood glucose was determined using a digital glucometer. Sperm count, motility, viability and morphology were assessed microscopically. Testes were histologically evaluated. Blood glucose levels were significantly higher in DNT (267.3 ± 6.6 mg/dL), DT1 (98.3 ± 1.3 mg/dL) and DT2 (87.5 ± 1.8 mg/dL) compared with CTRL (97.5 ± 1.0 mg/dL). Testes weights increased in DT1 and DT2 (1.0 ± 0.04, 1.0 ± 0.03 g) compared with DNT (0.7 ± 0.03 g). Sperm concentration increased in DT1 and DT2 (130.0 ± 5.9, 130.7 ± 7.3 x 106 cell/mL) compared with DNT (98.3 ± 2.3 x 106 cell/mL). Abnormal sperm morphology decreased in DT1 and DT2 (13.0 ± 0.9, 8.8 ± 0.4 %) compared with DNT (19.8 ± 0.9 %). Sperm motility increased in DT1 and DT2 (77.7 ± 1.5, 80.0 ± 0.0 %) compared with DNT (57.0 ± 1.5 %). Sperm viability increased in DT1 and DT2 (70.0 ± 0.0, 80.0 ± 0.0 %) compared with DNT (52.7 ± 1.3 %). Testes showed degenerated cells in DNT and no lesions in DT1 and DT2. Reduction in blood glucose, improved testicular functions and morphology showed that AMELE can be used to manage diabetes and its associated reproductive dysfunctions in male Wistar rats. Key words: Annona muricata, diabetes, streptozotocin, reproductive dysfunctions.