The study of vessel topography is highly relevant in vascular physiology since it can have a considerable effect in hemodynamics. Furthermore, vascular abnormalities or dysmorphic features are present in several cardiovascular disorders. Branching regions of vascular trees are common sites for dysfunctional blood flow patterns due to well-known biophysical factors. Several imaging technologies are useful to assess vascular topography, although their high cost limits their use in experimental physiology. In the last decade the so-called portable “vein finders” were introduced and their popularity has been considerably increasing. These devices use near-infrared or visible light to improve the contrast of superficial veins and facilitate their detection for venipuncture. However, their potential has been underexplored in vascular physiology. This pilot study aimed at quantitatively describing the branching topography of the superficial veins of the hand dorsum using a low-cost near-infrared vein finder. Five healthy subjects (25.5 ± 5.2 y.o.) participated in this study after giving informed consent. While sitting upright and with both hands at heart level, an image of each hand dorsum was obtained from each subject. From these images 30 bifurcating superficial veins were assessed using ImageJ®, which allowed the calculation of several branching parameters (branching angle, branching coefficient, angular asymmetry, area ratio, optimality ratios, length-to-diameter ratio, junctional exponent deviation). Linear correlations between these parameters were tested with the Spearman coefficient (p<0.05). Significant positive correlations were detected between the branching coefficient and area ratio, branching coefficient and optimality ratios and between the branching vessel diameter and the junctional exponent deviation. These results suggest that portable vein finders are useful tools for characterizing venous superficial vein topography. Further studies are needed to test their usefulness to assess venous perfusion in vivo.