The main concern is the high susceptibility of rabbits to stress and underlying respiratory disease (Flecknell, 1991; Meredith and Crossely, 2001). These problems necessitate careful choice of anesthetic regimen in the rabbits. Ketamine is popularly used to provide chemical restraint and anesthesia due to its wide margin of safety, compatibility with other anesthetic agents and ease of administration. The aim of the study was to determine the anesthetic effects of xylazine-ketamine-ketoprofen combination by assessing some anesthetic indices and physiological variables in healthy rabbits not undergoing any clinical procedure. Six rabbits with mean weight of (1.6 ± 0.1kg) were used for both the control and test experiment with a week interval between each trial, to allow a wash-out period for the drugs which is usually 72 hours period. The rabbits were sedated with intramuscular injection of 5 mg kg-1 xylazine, followed by concurrent intramuscular injection of 35 mg kg-1ketamine and 3 mg kg-1ketoprofen for the test experiment and exclusion of ketoprofen in the control group. The Heart rate, respiratory rate and rectal temperature were assessed following the loss of righting reflex and subsequently at 10 min interval over a period of 60 min. The Induction time, duration of recumbency and standing time were also recorded. Ranges of the mean heart rate, respiratory rate and rectal temperature with xylazine-ketamine-ketoprofen (XK-KP) combination were from 200.3 ± 14.8 to 211.3 ± 18.7 beats min-1, 35.0 ± 5.7 to 142.5 ± 24.1 breaths min-1 and 38.3 ± 0.4 to 38.8 ± 0.80C, while respective xylazine-ketamine (XK)values ranged from 174.8 ± 9.3 to 194.7 ± 11.4 beats min-1, 31.0 ± 5.9 to 94.5 ± 16.5 breaths min-1 ,and 38.2 ± 0.8 to 38.7 ± 0.70C. Data were expressed as Mean ± Standard deviation of six rabbits. A p<0.05 was accepted as statistically significant. The result showed that the anaesthetic effects of XK-KP compares well with XK, making it a good substitute in rabbit anesthesia. Concurrent administration of ketoprofen with xylazine-ketamine anesthesia was associated with shorter induction time (1.5 ± 0.5 min), longer duration of recumbency (77.0 ± 6.8 min) and shorter standing time (3.7 ± 2.2min) than the control values (1.8 ± 0.7 min, 73.7 ± 2.9 min and 6.3 ± 5.0 min). In conclusion, the hypnotic effect of xylazine-ketamine anesthesia was potentiated by concurrent administration of ketoprofen with the mixture.