Dementia is getting increasingly high with the time and according to National Centre for Social and Economic Modelling (NATSEM) Australia (1), the number of new cases of dementia will increase to 318 people per day by 2025 and more than 650 people by 2056. Despite of all the enormous progress in this field we are not getting any solution to this very serious problem. One of the reasons could be the presence of synthetic products in our food, for example a flavorant Diacetyl (DA), which is commonly used in the production of processed cheese and microwave popcorns. DA is structurally similar to MEG (methyl-glucuronic acid, known to induce Aβ aggregation) thus; an investigation into amyloidogenic effects of DA is clearly warranted. DA alone can induce amyloidogenesis at the concentrations as low as 25 μM, and even at lower concentrations of 1 μM (2). It is capable of permeating through blood brain barrier and is resistant to detoxify by glyoxalase system, thus promoting dicarbonyls formation in the brain (3). Curcumin is well known for its antioxidant, anti-inflammatory, and antitumor properties. Curcumin, due to its lipophilic nature can cross blood brain barrier, inhibit A-beta 40 aggregation, improving behavioral impairment (4). Aims and Objectives: The aim of this study is to test the anti-dementia effect of curcumin in DA induced animal models as to initiate appropriate strategies for the prevention of dementias such as Alzheimer’s disease (AD). Method and Material We used curcumin as a neuroprotective agent against Diacetyl (DA) induced dementia in male Wistar rats of 3-4 months of age. The rats were divided into 3 groups; two were injected with DA at a dose of 3.0g/kg for 10 consecutive days. Curcumin was given orally to the animals in group 3 at a dose of 80mg/kg. Animals were tested for the behavioral tasks using Rectangular maze test and locomotor activity test. Results: DA induced dementia like performance was observed using behavioral tasks tests including; Rectangular maze test and locomotor activity test. In DA treated animals, the correct response rate during acquisition and retention period was significantly lower than the control group. Neuroprotective effect of curcumin in DA induced memory loss rats was significantly virtuous and the values of both behavioral tests appear to be similar to that of the control group. Conclusion: We conclude that curcumin can act as a potential preventive agent for the DA induced dementia and amnesia. Key Words: Dementia; diacetyl (DA) memory loss rats; curcumin; Rectangular maze test and locomotor activity