During synaptic transmission small synaptic vesicles filled with neurotransmitter fuse with the plasma membrane to release their content. For maintaining synaptic transmission the exocytosed vesicle proteins have to be retrieved thereafter by compensatory endocytosis (1-3). What is the fate of synaptic vesicle proteins post fusion? Do they stay together in a raft-like structure (4), that can be retrieved efficiently in toto or do they disperse in the plasma membrane and have to be resorted and reclustered for retrieval? While it was recently shown that synaptic vesicles exocytosed and retrieved by compensatory endocytosis are non-identical with respect to their protein complement (5), this does not necessarily imply dispersion of vesicle proteins after fusion. By optically recording single fusion events with high-resolution scanning microscopy we show for four different transmembrane vesicle proteins, synaptobrevin 2, synaptotagmin 1, synaptophysin, and VGlut1, fast dispersion post fusion. Proteins diffused within the synaptic bouton membrane with diffusion constants around 0.2 µm2/s, but only 10 – 20 % were lost into the axonal membrane. This suggests a mechanism by which vesicle proteins are rapidly cleared from the release site to allow for the next docking and priming event, but are efficiently recaptured outside the active zone. Our findings at synapses tuned for high-fidelity signaling may hint at a general mechanism in organelle trafficking.