Data acquisition (DAQ) systems are widely applied in Physiology teaching and research (1, 2). This study investigated the impacts of using the PowerLab system (ADInstruments) on learning and laboratory experimentations in Physiology by medical students. This study was carried out among 55 pre-clinical medical students of Nile University of Nigeria, Abuja. A pretested self-administered questionnaire was used to evaluate the impacts of using the PowerLab system on students’ learning and laboratory experimentations in Physiology. The data were analysed using IBM SPSS Statistics (Windows) Version 22.0. Frequency distribution and summary statistics were analysed by descriptive analysis. Fifty-five (n=55) out of 90 pre-clinical students participated in this study. Fifteen (27.3%) respondents were males and 40 (72.7%) were females, with a mean age of 18.5 ± 1.0 years. More than 90% of the respondents are aware of the PowerLab system (n=51) and have used it to learn and conduct laboratory experiments (n=53). Majority of the respondents agreed that the use of the PowerLab system enhances their understanding of physiology experiments (n=50; 91%); stimulates imaginative and critical thinking skills (n=39; 71%); augments learning and comprehension of physiological concepts (n=45; 82%); boost engagement in learning and laboratory experimentations (n=47; 85.5%); and promotes active learning (n=50; 90.9%) amongst others. The use of the PowerLab system enhances pre-clinical medical students’ learning and laboratory experimentations in Physiology. This DAQ system provides students with state-of-the-art hands-on exposure to current teaching and research trends in the medical sciences and is now indispensable tools for quality medical education.