Introduction: Physical activity is an important part of the management of type 1 diabetes (T1D) and reduces the risk of associated complications. Many people with T1D exercise regularly. For safe exercise in T1D, in addition to glycemic control, it is important to recognise the differences in physiological response to exercise compared to healthy peers. Aim: We aimed to determine the changes in cardiovascular, respiratory and metabolic parameters in response to short-term submaximal exercise (SGSE) in recreational athletes with T1D compared to age- and sex-matched healthy controls. Methods: Eighteen recreational athletes, 9 per group, performed SGSE in the form of graded cycling on a cycloergometer until 85% of the maximal heart rate was reached, with 20 minutes recovery in a seated position. Cardiovascular (heart rate, mean arterial blood pressure (MAP)), respiratory (respiratory rate, ventilation) and metabolic (oxygen consumption, exhaled CO2 (VCO2)) parameters were measured non-invasively and averaged at three minutes before, one minute at the end and three minutes in recovery to SGSE. Cutaneous blood flow was measured using the laser Doppler method in the recovery phase after SGSE. Heart rate variability (HRV), heart rate recovery 30 and 60 seconds at the end of exercise, acral and forearm cutaneous vascular conductance (lnCVC), ventilatory equivalent for oxygen and carbon dioxide (VE/VCO2), respiratory quotient and the slope of oxygen uptake efficiency (OUES) were calculated. Normality was tested using the Shapiro-Wilk test. Data before, at peak power and after SGSE were compared for differences over time and between groups using a two-way ANOVA for repeated measures with Sidak adjustment for multiple comparisons. Independent samples t-test was used to determine differences between groups. Results: The expected temporal dynamics during exercise and its recovery were comparable in both groups for all measured parameters except MAP. The effect of exercise on MAP varied between groups: at peak exercise, MAP was significantly higher in the T1D group than in the control group (146.7±8.6mmHg in T1D; 129.8±11.2mmnHg in controls; p=0.002). There was a significant main effect of the group on VE/VCO2. At peak exercise and in the recovery, VE/VCO2 was significantly lower in T1D compared to control group (25.7±2.4 in T1D; 30.5±4.7 in controls; p=0.016 at peak exercise and 34.6±2.5 in T1D; 41±4.3 in controls; p=0.001 in the recovery phase). In addition, higher OUES (3833.8±1133.1 in T1D; 2761.0±576.4 in healthy subjects; p=0.0396) and lower forearm lnCVC (-2.4±0.4 in T1D; -1.1±1.2 in healthy subjects; p=0.009) were observed in T1D compared to controls. Discussion and conclusion: The response of recreational athletes with T1D to SGSE differed from healthy subjects primarily in MAP and ventilatory response, which may be attributed to the differences in baroreflex and chemoreflex described in T1D compared to healthy participants. Cutaneous forearm blood flow after exercise is decreased in T1D compared to control subjects, which confirms the previously described decreased ability to excrete heat in T1D and may be related to differences in autonomic nervous system activity on the vasculature in T1D. Further studies are needed to confirm these conclusions and possibly uncover the mechanisms underlying our findings.