Introduction. Activation of leukocytes is an important component of the therapeutic effect of the low-volume hemoperfusion method, which consists in contact induction of bioactive substances and activated cells in the blood and delivery of the altered spectrum of activity to the lesion focus. In this method, we used the SKT-6A-VCh carbon sorbent, tested in the clinic with a positive effect when it is included in the treatment regimens for limb diseases(1). According to the results of the studies, Silochrome S-120 has the best characteristics of hemocompatibility and the possibility of further modification, which is significant for the development of new technologies for low-volume hemoperfusion(2),(3),(4). Materials and methods. Experiments to study the activation properties of foreign surfaces were carried out in bench conditions. As blood-contact preparations, we used: carbon hemosorbent of gloom SKT-6A-VCh and a sorbent based on silica – Silokhrom S-120. SKT-6A-VCh is a high-purity medical carbon hemosorbent approved for use in clinical practice as a hemosorbent and as a hemoactivator in the procedure of low-volume hemoperfusion. Silochrome S-120 – irregular white granules, 0.3-0.5 mm in size. The specific surface of the granules is 130 m2 / g, the pore size is 28 nm. Donor blood was taken from healthy volunteers from the cubital vein into a 9.0 ml vacuum tube with heparin. The activation of leukocytes was assessed using the method of lucigenin-induced chemiluminescence on a chemiluminometer “Lum-1200”. 14 experiments were performed, 7 with each of the studied sorbents. Luceginin prepared by dissolving the luceginin matrix in Hanks solution in a ratio of 1:25 was added to a test tube with a volume of 3 ml and a diameter of 12 mm. The matrix was prepared by diluting 5.8 mg of luceginin with 10 ml of dimethyl sulfoxide. Then the Hanks solution was added to the test tube to 0.9 ml and 0.1 ml of donor heparinized (16 IU per 1 ml) blood. The assessment of the activity of leukocytes was carried out within 1 hour from the moment of contact of the blood with the sorbent according to the maximum chemiluminescence and light sum per granulocytes. Granulocyte count was performed by flow cytometry on hematologic analyzer SySmex XT 1800i. Statistical analysis was performed in “RStudio” and “Excel 2019” by parametric methods: Shapiro-Wilk test, unpaired Student’s t-critrea. Differences were considered significant at p<0.001. Results. • Upon contact of blood with the drug "Silochrome S-120", the maximum chemiluminescence was 0.252±0.059 kPPS in the time interval 14.48 ± 1.583 min and the light sum was 81,8±18,85 kPPS*s per granulocytes*109.  • Upon contact of blood with the drug with SKT-6A-VCh, the maximum chemiluminescence was 0.257±0.077 kPPs in the time interval of 9.05 ± 2.500 min and the light sum was 92,3±25,06 kPPS*s per granulocytes*109.  Conclusion. Contact induction of activated leukocytes in the blood on the preparation Silochrome S-120 does not differ from the reference sorbent SKT-6A-VCh, but the activation of leukocytes on this preparation occurs later in time, which must be taken into account when using it in medical technology.