Diving with self-contained underwater breathing apparatus (SCUBA) leads to endothelial dysfunction and the elevation of circulating microparticles (MPs) that could initiate a systemic inflammatory process after resurfacing. An impaired endothelial function has also been observed following acute periods of oscillatory shear stress in the conduit arteries. The aim of this study was to assess whether the vascular endothelium is more susceptible to induced oscillatory shear stress following SCUBA dive. Twelve male divers (age 39.3±9.2 years, height 186±6 cm, weight 88.0±11.6 kg) completed a single dive to a depth of 18m sea water with a 47-min bottom time. Subgroups of endothelium-derived (CD31+/CD41b-), platelet specific (CD41a+) and platelet-endothelium adhesion molecule (CD31+) MPs were assessed before and after an intervention of imposed oscillatory shear stress by a 20-min cuff inflation to 75 mmHg over the forearm, pre- and post-dive. Endothelium derived CD31+/CD41b- MPs remained unchanged pre- and post-dive and intervention. Diving induced an increase in CD31+ and CD41a+ (p<0.05). Oscillatory shear stress increased CD31+ and CD41a+ pre-dive (p<0.05), but not post-dive (p>0.05). Some markers of endothelial function and platelet activation seem to be susceptible to oscillatory shear stress pre-dive, but resistant post-dive.
Europhysiology 2018 (London, UK) (2018) Proc Physiol Soc 41, PCB170
Poster Communications: Diving-related microparticle responses following imposed oscillatory shear stress
O. F. Barak1, R. L. Hoiland2, S. Thom4, T. Mijacika3, D. Vlahovic1, P. Jovanov5, Z. Dujic3
1. Department of physiology, Faculty of Medicine, Novi Sad, Serbia. 2. University of British Columbia, Okanagan Campus, Kelowna, British Columbia, Canada. 3. University of Split School of Medicine, Split, Croatia. 4. University of Maryland School of Medicine, Baltimore, Maryland, United States. 5. Institute of Food Technology in Novi Sad, Novi Sad, Serbia.
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