Ou MC decrescendo phenomenon treatment (OuDPt) reduces pain or inflammation in an area by placing the contralateral hand along human body anatomical axis (HBAA) over the lesion (Proc Physiol Soc 2014-6).1. More HBAAs interaction shows to be more competent to induce tumor regression, which evinces that the effect of OuDPt is associated with HBAAs interaction.2 59 patients with dysmenorrhea received OuDPt in menstrual period. Another 10 patients had recurrent dysmenorrhea about 6 months to 2 years after laparoscopic operation for chocolate cyst and endometriosis. Co-existing infection should be treated for that OuDPt may not be always effective against infection. These 10 patients received OuDPt in a 2 dimensional way twice daily and performed more in the menstrual period on the painful area.2 All the dysmenorrhea of the 59 patients were alleviated by OuDPt. For the 10 patients after endometriosis operation, OuDPt also shows to alleviate the menstrual pain prominently to date that they do not need other analgesic treatment. The interaction of HBAAs in this study showed to alleviate dysmenorrhea which is mainly caused by inflammatory reaction. Alleviation of pain, cessation of uterine bleeding, improvement of organ dysfunction, and elimination of malignant changes by OuDPt suggests the restoration of normal tissue function.2,3,4 Normal cell polarity is essential to normal tissue function. Signaling system of embryonic axes has shown to impart polarization of individual cells and the tissue function normalization by HBAAs interaction in our studies may also be via the regulation of cell polarity. Recent studies show disruption of cell polarity increases inflammatory reaction.5