Parkinson’s disease (PD) is a chronic progressive neurodegenerative disorder characterized by early prominent death of dopaminergic neurons in the substantia nigra pars compacta (SNpc) and wide spread presence of alpha synuclein (aSyn). Dopamine deficiency in the basal ganglia leads to classical Parkinsonian motor symptoms viz, bradykinesia, tremor, rigidity and later postural instability. Parkinsonism is also associated with non-motor symptoms, which may precede motor symptoms by more than a decade. Resveratrol (3, 4′, 5- trihydroxystilbene) is a nutraceutical that has recently attracted a lot of research attention due to its exciting pharmacological potentials. It is a phytoalexin found in many plants including grapes, peanuts. This study investigated the effect of resveratrol on mechanical nociception in rotenone induced Parkinson’s disease in mice using Randall sellito analgesiometer. Forty eight (48) animals were randomly assigned into six (6) groups of eight (8) animals each. Group 1 (control group) was administered distilled water, group 2 was administered Dimethyl sulfoxide (DMSO) only. The group 3 were administered rotenone only while the other groups were administered rotenone and resveratrol at a dose of 10, 20, 40 mg/kg.  The average mechanical threshold in Rotenone only group was (10.96 ± 1.64 g) increased compared to the control group (10.52 ± 0.35 g) but the increase is not significant (p > 0.05). The mechanical threshold for the Rotenone + RSV treated groups is as follows: Rotenone + RSV10 mg/kg (8.75 ± .49), Rotenone + RSV 20 mg/kg (7.97 ± 0.48 g) and Rotenone + RSV 40mg/kg (9.63 ± 0.60 g). The results suggest that resveratrol did not significantly influence mechanical nociception in rotenone model of parkinson’s disease.