Background- Postmenopause comes with its constellation of adverse health events,metabolic syndrome being one of the leading factors of morbidity and mortality.Yoga has been described as having beneficial effect on HOMA-IR and lipid profile in various populations. Methods and Materials-67 women within five years of menopause between 45 and 60 years of age attending menopause clinic of Smt. Sucheta Kriplani Hospital fulfilling inclusion and exclusion criteria and consenting were enrolled for study with permission of Institutional Ethical Committe. Subjects were divided into 37 cases and 30 controls on the basis of their willingness to learn and practice Yoga. The cases received intervention in the form of Integrated Yoga for12 week under a trained Yoga instructor from Naturopathy and Lifestyle Intervention Centre,Lady Hardinge Medical College.Fasting blood samples were collected from the subjects for serum insulin, blood glucose and atherogenic lipid profile at baseline and 3 months post intervention.HOMA-IR was calculated as per U.S. formula.Statistical analysis was done using Graph Pad Prism Version 6 software.Values are means ± S.E.M., compared by paired t-test.Statistical significance was set up at p< 0.05.Result-In the control group, a significant increase in Fasting S. Insulin (7.94±1.03 pre vs 9.65±1.09 post, p=0.0066) and HOMA-IR(2.17±0.31 pre vs 2.62±0.37 post, p=0.0212) was observed at the end of 3 months. Fasting S. Insulin (6.52±0.49 pre vs 7.41±0.52 post, p=0.1681) and HOMA-IR(1.56±0.11 pre vs 1.76±0.12 post, p=0.1801) in the Yoga group showed a non-significant trend towards increase. Fasting blood sugar in the Yoga(97.95±2.52 pre vs 97.51±2.76 post, p=0.8414) and Non-Yoga(106.9±5.13 pre vs 105.7±4.70 post, p= 0.8119) groups did not show any significant changes. The atherogenic lipid profile in the Yoga Group[Total Cholesterol/HDL (4.25±0.19 pre vs 4.08±0.1417 post, p=0.7247), Serum Triglycerides/HDL(2.87±0.22 pre vs 2.82±0.26 post, p=0.2482), LDL/HDL(2.68±0.16 pre vs 2.5±0.12 post, p=0.5071),Non-HDL(141.3±5.603 pre vs 141.1±5.31 post, p=0.9804) and A.I.P(0.42±0.029 pre vs 0.39±0.037 post, p=0.8712)] and Non-Yoga Group [Total cholesterol/HDL(4.463±0.18 pre vs 4.526±0.18 post, p=0.9018), Triglycerides/HDL(3.56±0.28 pre vs 3.62±0.34 post, p=0.6190), LDL/HDL(2.738±0.15 pre vs 2.815±0.144post, p=0.9508),Non-HDL(144.4±6.265 pre vs 151.8±5.58 post, p=0.1413) and A.I.P.(0.51±0.04 pre vs 0.52±0.03 post, p=0.8120] showed no significant changes post intervention.Conclusions-Three months duration of Yoga practice attenuated the tendency for rise in insulin resistance in the case group and hence may be used as a strategy to delay or prevent the onset of insulin resistance associated with early postmenopause. Longer studies on larger sample size is needed to elucidate the effect of Yoga on atherogenic lipid profile in our population.