Uptake of aluminum may disturb the learning and memory of humans or animals. But zinc has been shown to exert beneficial effects on memory deficits. Objective: The aim of the present study is for evaluating the effect of zinc chloride on aluminum-induced learning and memory impairment in rats. In this research, we examined coadministration of zinc chloride(30mg/kg/day) and aluminum chloride (600mg/kg/day) in drinking water for two weeks. The shuttle box was used for this text. Also we used gavage method for oral administration. Two criteria were considered to behavioral test, including latency in entering dark chamber and time spent in the dark chamber. This experiment showed that after 2 weeks coadministration of Zncl2 (30mg/kg/day) and Alcl3 (600mg/kg/day) doses, passive avoidance memory has been improved (P<0.001). In conclusion: zinc chloride consumption with (30mg/kg/day) dose, could have a significant effects on memory and could improved the negative effect of Alcl3 on learning and memory. It seems zinc modulated NMDA receptor, which participate in memory formation, and could enhance LTP in the CA1 region of the hippocampus in aluminum-induced learning and memory impairment in rats. Also, zinc adequate doesn’t permit the entry in the brain of toxic metals such as aluminum, from blood-brain-barrier (BBB).