Effects of Zingiber officinale on reproductive functions in male rats

University of Cambridge (2008) Proc Physiol Soc 11, PC156

Poster Communications: Effects of Zingiber officinale on reproductive functions in male rats

A. O. Morakinyo1, A. P. Arikawe1, O. S. Adeniyi2

1. Physiology, College of Medicine of the University of Lagos, Lagos, Lagos, Nigeria. 2. Physiology, College of Health Sciences, Benue State University, Makurdi, Nigeria.

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AIM: To investigate the effects of Zingiber Officinale on male reproductive functions and study the mechanisms underlying these effects. METHODS: Aqueous extract of Zingiber Officinale were administered orally to two groups of male rats at 500mg/kg b.w. (Group 2) and 1000mg/kg b.w. (Group 3). Group 1 served as control and received distilled water which is the treatment vehicle. Treatment lasted for 14 and 28 days before sacrifice. Organ weight, epididymal sperm counts, motility, viability and morphology, seminal fructose, testicular malonhydialdehyde, and serum testosterone were determined. RESULTS: The treatment caused a significant increase (P<0.05) in the weight of the testis and epididymis. There were dose and duration dependent increases in sperm count and motility (P<0.05). There was also a significant increase (P<0.05) in serum testosterone level. Malonhydialdehyde levels were significantly reduced (P<0.05). CONCLUSION: Our results indicated that extract of Zingiber Officinale possesses pro-fertility properties in male rats which might be a product of both its potent antioxidant properties and androgenic activities.



Where applicable, experiments conform with Society ethical requirements.

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