Enhanced spermiogram in Cinnamon verum treated male alloxan – induced diabetic Wistar albino rats

Physiology 2015 (Cardiff, UK) (2015) Proc Physiol Soc 34, PC064

Poster Communications: Enhanced spermiogram in Cinnamon verum treated male alloxan – induced diabetic Wistar albino rats

O. E. Adeleye1, O. B. Akinlabi1, A. S. Adetomiwa3, A. I. Adeleye2

1. Veterinary Physiology and Pharmacology, College of Veterinary Medicine, Federal University of Agriculture, Abeokuta,, Abeokuta, Nigeria. 2. Veterinary Teaching Hospital, College of Veterinary Medicine, Federal University of Agriculture, Abeokuta,, Abeokuta, Nigeria. 3. Veterinary Public Health and Reproduction, College of Veterinary Medicine, Federal University of Agriculture, Abeokuta,, Abeokuta, Nigeria.

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A major global health issue is infertility and about 30% is due to male factors (Isidori et al., 2006) and diabetes mellitus interferes with reproductive function in laboratory rats (Valdes et al., 1990).Several medicinal plants lower blood glucose level in experimental animals (Khan et al., 2003). Whether use of Cinnamon verum spice can lower the hyperglycaemia and have an effect on the reproductive ability in diabetic male Wistar albino rats is unclear and the purpose of the present study. 25 male rats were randomly assigned to 5 groups. Control {(CON) 0.5 mL kg-1 body weight distilled water intraperitoneally, n = 5}, Diabetic control {(DC) Alloxan intraperitoneal (IP) injection of a single daily dose of 150 mg/Kg b.wt. for 3 consecutive days (Ashok et al., 2007), n = 5}, Cinnamon {(CIN) 500 mg of Cinnamon verum spice solution (CVSS)/kg b.wt., per os by intragastric gavage, n = 5}, and Two test groups {(250 CIN and 500 CIN) Alloxan IP injection of a single daily dose of 150 mg/Kg b.wt. for 3 consecutive days, 250 mg and 500 mg of CVSS/kg b.wt., per os respectively, n = 5}. All rats were kept in standard conditions, fed and watered ad libitum for 65 days. ​Blood glucose was measured weekly. Rats were humanely sacrificed on the last day and sperm collected from epididymis. Values were expressed as mean ± standard deviation and Student’ t-test was applied to test the significance of differences between groups with accepted significant level p < 0.05.Results showed that administration of both 250 mg (124.2±11.2 mg dL-1) and 500 mg (119.78±3.8 mg dL-1) of CVSS decreased blood glucose level in a dose-dependent manner (p < 0.05), improved sperm livability (82.5 ± 2.5% and 80.0 ± 5.0%) and motility (77.5 ± 2.5%, 77.5 ± 2.5%) of treated diabetic rats when compared with diabetic control rats (239.4±4.5 mg dL-1, 65.0 ± 3.0%, 57.5 ± 2.5%) (p<0.05). CVSS caused a 12.6% decrease in blood glucose levels of the 250 CIN diabetic rats within 1 week of administration compared to 15.1% for the 500 CIN within the same period. The maximal reduction of 42.6% was observed at 4 weeks for 250 CIN, while for the 500 CIN the maximal reduction of 31.0 % was observed at 3weeks and 23.6% at 4 weeks post administration of extract. CVSS (250 and 500 mg/kg) significantly lowered blood glucose levels of alloxan diabetic rats (p<0.05) when compared with control rats treated with distilled water. It can now be deduced from this study that CVSS while having hypoglycaemic effect consistent with the findings of Khan et al.(2003) also improves sperm motility a powerful factor for male reproductive capabilities and sperm concentration (Jensen et al., 2006) of male diabetic rats thereby enhancing fertility.



Where applicable, experiments conform with Society ethical requirements.

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