Objective: we aimed to assess bone status in children suffering from a chronic haemophilic arthropathy of lower limbs and also to search factors associated to osteopenia.Methods: in this cross-sectional study, we studied bone status in children suffering from chronic hemophilic arthropathy of lower limbs (hips, knees, ankles). Clinical characteristics, haemophilic arthropathy features and anthropometric measurements were noted. Bone mineral density (BMD) in lumbar spine and total body were determined using dual X-ray absorptiometry and Z-scores were calculated. Osteopenia was defined by a Z score<-2 SD.Results: Twenty seven haemophilic patients (haemophilia A (N=22) and B (N=5)) suffering from a chronic haemophilic arthropathy of lower limbs participated in this study. Haemophilia was severe in 85% of patients. All patients received factor replacement in haemorragic situations. Two patients were on prophylactic factor therapy. Twenty patients have arthropathy of the knee and ankle. Nine children (33%) have osteopenia. Patients with hemophilia A and severe forms have reduced bone density (respectively p= 0.001, p= <0.0001). No obese child had osteopenia (p= 0.01). Patients with radiological injuries have more osteopenia (respectively, p= 0.01). Presence than more than one arthropathy was related to presence of osteopenia (p= 0.01). Severe arthropathy (defined by radiologic assessement) was also associated to osteopenia (p= 0.01).Conclusions: This study suggested that severity of haemophila and of chronic srthropathy were the main factors associated to presence of osteopenia in children suffering from haemophilia. Reduced bone density should be screened in children suffering from chronic haemophilic arthropathy of lower limbs to avoid a considerable reduction in bone density that might result to further fractures and skeletal fragility. Future larger studies are needed to confirm our results.