Since early day biologists, biochemists and physiologists have been conducting experiments in animals and their tissues to gain understanding of the principles of life. Putting humpty dumpty back together again has proven to be yet another thing. Here, computational modeling presents a valuable investigative tool by offering a precise framework to capture and integrate what has been learned about a particular subject matter and generate testable predictions that may be then be verified against experimental observation. Importantly, such numerical models can help experimentalists identify what particular measurement should next be made in order to rigorously test a particular hypothesis. This talk will highlight these beneficial uses of computational modeling in physiology.