Liver plays a major role in detoxification and excretion of many endogenous & exogenous compounds. Liver diseases are major health problem worldwide & caused by infection, autoimmune disorder, toxic agent & drugs1. Synthetic drugs used in the treatment of liver diseases are inadequate & may have serious side effects2. Terminalia chebula (T.chebula) have been in use in folk medicine in Bangladesh since ancient times3. The objective was to observe the hepatoprotective effects of T.chebula on paracetamol induced liver damage in Wister albino rats. With the permission of Ethical Review Committee, this study was carried out in the Dept. of Physiology, Dhaka Medical College,Dhaka, Bangladesh(Jan’13-Dec’13). A total of 44 rats (age 90 – 120 days, wt 150 – 200 g) were selected & kept in a standard laboratory condition for 14 days’ acclimatization then studied for 21 days. All the rats had access to basal diet. They were divided into control groups (grs) (n=22) & experimental grs(n=22). Control grs were subdivided into gr A (base line control n=11) & gr B (paracetamol treated control n=11). Experimental grs were subdivided into gr C (T.chebula pretreated and paracetamol treated n=11) & gr D (paracetamol pretreated and T.chebula treated n=11).Initial body wt was measured on the 1st day. Gr A received propylene glycol (2ml/kg body wt orally) & gr B received single dose of paracetamol (750mg/kg body wt orally) on 21st day. In experimental grs, gr C received T. chebula (200 mg/kg body wt orally) for 21 days and paracetamol (750mg/kg body wt orally) on 21st day. Gr D received paracetamol (750mg/kg body wt, orally) on the 1st day & T.chebula (200 mg/kg body wt orally) for 21 days. Final body wt was measured on 22nd day then rat was sacrificed by decapitation after anesthetized with 30% chloroform. The liver was removed, weighted & preserved in 10% formalin for histological processing. Statistical analyses were done by one way ANOVA, Bonferroni test and Fisher’s exact test as applicable. The mean (+SD) liver wt was 4.11±0.59, 2.85±0.69, 3.82±0.75 & 3.64±0.59 gm in gr A, B, C and D respectively. The liver wt was significantly (P<0.001) lower in gr B than gr A & significantly (P<0.001) higher in gr C and D than gr B. The histological examination of liver revealed normal findings in 100% of rats in gr A, while it was abnormal in 100% of rats in gr B. In gr C, 90.9% of rats showed almost normal structure, but 9.1% showed mild histological changes in liver. Again 81.8% of rats in gr D showed almost normal structure, whereas 18.2% showed mild histological changes in liver. There were also improvements of histological changes in liver in gr B & D. The % of histological changes in liver of rats were significantly (P<0.001) higher in gr B than gr A, C and D. It may be concluded that T.chebula has hepatoprotective effects in paracetamol induced liver damage in rats.