Urge urinary incontinence (UUI) is a widespread clinical problem characterised by involuntary leakage of urine accompanied or preceded by “a sudden compelling desire to pass urine which is difficult to defer” (Abrams et al, 2002). One approach to mitigate this condition would be to inhibit bladder emptying via short term block of efferent activity in the pelvic nerve at the first sensation of urgency, thus ‘buying time’ to reach a toilet. To test the concept we investigated whether high frequency electrical stimulation of the pelvic nerve could inhibit reflex voiding during continuous cystometry in anaesthetised rats. Female urethane anaesthetised Wistar rats (n=15) (1.4g Kg-1 i.p.) were instrumented to record blood pressure, heart rate, tracheal air flow and for intravenous infusion of fluids. Rectal temperature was maintained at 37oC. The left preganglionic pelvic nerve bundle was exposed via a laparotomy and fitted with a bipolar cuff electrode for stimulation. Catheter was inserted via the bladder dome to allow infusion of saline and simultaneous recording of bladder pressure. A balloon catheter was used to monitor pressure within the uterus (n= 8) or rectum (n=4). Continuous infusion of saline into the bladder (6ml h-1) evoked repetitive cycles of filling and voiding (0.32-1.96min-1). Unilateral pelvic nerve stimulation (1-3kHz sinusoidal waveform, 1-5mA for 60s) initiated within 1s of the onset of the sharp rise in bladder pressure signalling an imminent void aborted the void and no urine was expelled. Urinary continence could be maintained for the entire 60s stimulation period but voiding resumed within 60s of stimulus offset. High (10kHz) or low (500Hz) stimulation did not block micturition (See figure). Cardiovascular/respiratory effects were minimal and there was no significant change in intra-uterine or rectal pressure. Stimulation applied during filling i.e. in between voids produced only small transient ‘on’ and ‘off’ fluctuations in bladder pressure. We conclude that unilateral high frequency electrical stimulation of the pelvic nerve is sufficient to suppress an imminent void and prevent urine release, without causing significant ‘off-target’ effects. This technique may hold therapeutic potential for management of Urge Urinary Incontinence.