Background and aims: Neurocognitive function assessment (NFA) consists of a battery of psychometric tests designed to challenge memory, mental agility and co-ordination and is traditionally used to assess the effect of a vascular surgical intervention (e.g day before surgery and 24 hours, 5-7 days and/or 6 weeks post-operatively) such as coronary artery graft by-pass (1) and carotid endarterectomy (2). However, changes typically recorded post-operatively may be misinterpreted as a consequence of a 24% improvement in score, which was identified when NFA was repeated over 4 days (3). As a result, post-operative NFA scores, may in fact underestimate the degree of neurocognitive decline or alternatively, overestimate neurocognitive improvement observed post-operatively. In the present study we aimed to identify if i) the learning process continues over 8 days and ii) a learning effect exists despite a 6 week gap between tests. Methods: 30 healthy volunteers performed 4 consecutive days of testing, while 10 were tested for a further 4 days. A separate cohort of 15 subjects was tested on 2 separate occasions, 6 weeks apart. All participants completed a battery of psychometric tests, randomly administered and performed at a similar time of day. The tests included the core tests according to the recommendations of the statement of consensus on the assessment of neurobehavioral outcomes after cardiac surgery (4). The battery of tests were further grouped into 3 specific domains; i) Memory ii) Mental Agility iii) Visual-motor Co-ordination. Results: Detailed results are provided in Table 1. We confirmed our previous findings (3) showing an improvement over 4 days (P < 0.05). Thereafter, NFA score began to plateau. In addition, significant improvements in all memory and mental agility tests (P < 0.05) were recorded in those who repeated the tests 6 weeks apart. Conclusion: These findings are the first to identify that NFA scores stabilise after 4 consecutive days of testing. Furthermore, the learning effect is apparent despite a 6 week break between tests. Further research is required with a greater sample size to confirm these preliminary observations.