Nonpharmacologic therapy is a key strategy in the management of dyslipidemias. Lipid ratios that identify the pro-artherogenic and anti-artherogenic fractions perform better in predicting cardiovascular risk than individual lipid levels [1,2]. There is a dearth of studies on effect of dietary restriction on these ratios in healthy adult Nigerians. This study was designed to evaluate the effect of intermittent dietary restriction on lipid ratios in apparently healthy young adults using the Ramadan model [3]. Ethical approval was obtained from Lagos State University College of Medicine Research and Ethics Committee. Written informed consent was obtained from all the volunteers. Experiments were carried out one week before (1BF) and in the 4th week of, the Ramadan fast (4WF). After obtaining subjects’ height (m) and baseline body weight (kg), venous blood was collected about 12 hours after the early morning meal at 1BF. Subjects then had calorie and fluid restriction from sunrise to sunset [2] during the 30 days of Ramadan fasting. Repeat body weight measurement and collection of venous blood were carried out during the 4th week (4WF). The blood was analyzed for total cholesterol (TC), triglyceride cholesterol (TG), high density lipoprotein cholesterol (HDL-C) and low density lipoprotein cholesterol (LDL-C). Non-HDL cholesterol was calculated as the difference between TC and HDL-C. Body Mass Index (BMI) was calculated as weight/height2 (kg/m2). Values are presented as mean ± S.E.M. Paired Student t test was used to compare within group while Pearson correlation was used to determine relationship between BMI and the lipid ratios. Differences were accepted as significant at 95% confidence interval. Fifty healthy adults (19 females and 31 males), mean age 23.30 ± 0.71y participated in the study. Mean BMI reduced significantly from 22.87± 0.44 kg/m2 (1BF) to 22.23± 0.45 kg/m2 (4WF), p < 0.0001. All lipid ratios were significantly reduced as follows: total cholesterol: high density lipoprotein (TC/HDL-C) from 4.17 ± 0.10 (1BF) to 3.54 ± 0.10 (4WF), p < 0.0001; triglyceride cholesterol/high density lipoprotein (TG-C/HDL-C) from 0.88 ± 0.06 (1BF) to 0.7 ± 0.01 (4WF), p = 0.002; low density lipoprotein/high density lipoprotein (LDL-C/HDL-C) from 2.77 ± 0.1 (1BF) to 2.22 ± 0.1 (4WF), p < 0.0001 while Non-HDL/HDL reduced from 3.17 ±0.1 (1BF) to 2.54 ±0.1 (4WF), p < 0.0001. There was no significant correlation between BMI and any of the lipid ratios; however, ΔBMI was significantly correlated with ΔNon-HDL/HDL, r = -0.31, p = 0.03. We conclude that 4-weeks’ intermittent dietary restriction reduced BMI and lipid ratios and may be a useful nonpharmacologic therapy in the management of dyslipidemias and thus the control of cardiometabolic diseases.