The ureteral smooth muscle is characterized by a highly autonomous zone, acting as a pacemaker in pyeloureteral anastomosis. Stable slow automaticity promotes the subsequent emergence of spikes along with the ureter, which in turn provides the primary functional significance of the organ is peristaltic activity (1). The ability of each ureteral individual cell to generate spontaneous electrical waves of excitation can assume about the existence of various rhythmogenic zones (2). The subsequent identification of automatism also in the bordered area to the bladder pushes the task of studying the mechanisms of interaction between the two rhythmogenic regions in order to ensure functional activity of the whole ureter (3). All experiments were carried out in situ on white “Albino” rats (300-350g, n=12) anesthetized by Nembutal (50-55mg/kg) intraperitoneally. The ureter was denervated by the section of the splanchnic and pelvic nerves roots. The spike activity was registrated with silver bipolar electrodes, the slow wave activity with silver monopolar ball electrodes by 8-channel EEG. Analysis of the results was carried out using modern packages Lab View software and Origine-8. All experiments were verified by the t-student test. The histamine was used (Sigma-Aldrich, Germany). The drug was injected into the femoral vein (in 0.2 ml solution) in different concentrations: 10-6, 10-5 and 10-4 Mol/l (n=9). Morpho-histochemical studies were performed by the orthophosphates detection method. This method allows tracking the smallest functional changes in cellular structures of the organ. All procedures are performed according to “principles of laboratory animal care” (NIH publication 85-23 revised 1985). The killing was carried out with a lethal dose of anesthetic. The automatism of perirenal zone is 22±2.05 and peribladder:11±0.67, n=13, p<0.01 under normal conditions in rat. The effect of disturbances of propagating spontaneous activity of pyeloureteral anastomosis to the bladder has been studied. The local cooling of the middle portion of ureter showed a small increase (up to 20-22%, n=10) of slow waves genesis of peribladder zone. Conduction disturbance between two ending zones of the rat ureter is also realized by the transection of ureter in its middle part. After a certain period of time in all cases, there was decrease in the frequency of primary pacemaker: 17±1.8 oscillations/min, p<0.01 and, respectively, passing the spikes. However, there is some increased frequency of slow waves in the junction of the ureter to the bladder (4). These data show the impact of the primary ureteral rhythmogenesis on the automatism of distal zone: excitatory propagating waves some reduce the genesis of distal autonomous waves. Of all the variety of physiologically active compounds, changing the excitability of the membrane of ureteral smooth muscle tissue, the histamine causes a certain interest which is able not only to regulate spontaneous activity, but create slow pacemaker oscillations of membrane potential. Such regulation is associated with a high prevalence in the tissues of this organ with one hand H1-histamine receptors, and with another- the presence of mast cells capable of releasing histamine (5). The subsequent injection of histamine into the femoral vein of the animal at a concentration of 10-4Mol/l leads to a sharp change of certain characteristics of both types of electrogenesis. The increasing rhythm as slow waves as well action potentials has been observed: 24.5±2.6 oscill/min (n=9) increase to 44.3±4.2 oscill/min, n=12, p<0.01. It is noted also the improving of conductivity and each spike that occurs on the base of a slow wave, as a rule, reaches the peribladder zone. The regulatory role of histamine is expressed by activation of ureteral renal zone rhythmogenesis. It is also shown improvement in the conductivity of the propagating wave of excitation to the bladder, and the disturbed coordination of spike activity with slow waves in bordered area with bladder. Morphological analysis of the effect of histamine showed intense staining of cellular elements of the muscular layer in the area of kidney and bladder sections of ureter, which indicates a high functional status of these areas. Slow-wave activity of peribladder area can be connected to the above-noted leadership role under the suppression of kidney automatism, or transection of the ureter. Lack of coordinated activity between the two ending zones of the ureter may indicate a backup role of peribladder pacemakers in norm. The peribladder area of the ureter, despite the relatively low-frequency of spontaneous activity in comparison with the basic renal pacemaker is characterized by polymodality and may provide a functional role of the ureter.